Illuminating
the Spectrum
of Spatial Discovery
Platform
REBUS ESPER™
A Whole New Dimension in Biological Research – Cells in Detail AND in Context
The Rebus Esper is a fully integrated, automated instrument that delivers high-throughput, quantitative, single-molecule, single-cell data with spatial context and subcellular resolution by bringing together advancements in imaging, fluidics, chemistry and bioinformatics.
Analyzing cells at the molecular level while maintaining spatial context is key to understanding these fundamental units of life.
RESOLUTION
SCALE
SPEED
Next generation SAO optics
A 20X lens delivers 100x resolution – 81nm pixel size
Deep tissue imaging
Over 3um of sample depth per Z-plane to maximize counts from each cell
Large imageable area of 3cm2
Enables processing multiple samples in one run, lower cost per sample, and less variability
High single cell throughput
Wide 20X field of view captures more cells per image
Subcellular & single cell data generation
Quantify single RNA molecules for accurate cell state analysis
Runs multiple assays
Versatility from discovery to validation
Technology
Integrated & Automated
Every component of the Rebus Esper spatial omics platform has been developed to work together to deliver high-resolution, high-throughput data while maintaining ease of use and walkaway operations.
Applications
Spatial Context – Biological Insight
A holistic understanding of cells in their native tissues is key to unlocking new discoveries in neuroscience, cancer, infectious disease, immunology and developmental biology.
Software
Interact with your Data
QC every step of image processing, edit data to perfection, and explore your spatial data to discover biological insights.
Imaging
Synthetic Aperture Optics (SAO)
The Heart of the Rebus Esper™
At the heart of the Rebus Esper is our patented Synthetic Aperture Optics or SAO, which allows image-based spatial analysis of single cells with no compromise between resolution, scale and speed.
The sample is illuminated by a series of high-resolution light patterns that are created by the interface of excitation laser beams.
Videos
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See for yourself
Rebus Esper™ delivers biology at every scale: From the anatomical to the molecular
Data at different scales – from the anatomical to the molecular – is key to understanding the biology of tissues. The Rebus Esper enables analysis of cells in their native tissue context at high throughput. Get rapid analysis of biological molecules directly in and across large tissue sections with pristine subcellular details.