Resolution, scale & speed

High-quality, High-throughput Data

The Rebus EsperTM is an integrated, automated spatial omics platform that delivers quantitative single-molecule, single-cell data with subcellular resolution.

Advanced imaging, on-system chemistry, and intuitive software are brought together into a single system, providing a streamlined, end-to-end solution requiring minimal hands-on time.

Imaging data is processed automatically to output a spatially-annotated CellxFeature matrix that can be used with your favorite software for single cell analysis and precise spatial mapping.


Rebus Esper Spatial Omics Platform

  • Subcellular resolution
  • Image large or multiple sections
  • Rapid data acquisition and processing
  • Multi-assay capability
  • Minimal hands-on time
  • Walkaway operation


Analyze biological molecules directly in and across large tissue sections with pristine subcellular detail


Data from large single sections or multiple smaller sections in a single run


Tens of millions of data points from hundreds of thousands of cells in less than two days


Read more about the Rebus Esper


Streamlined Workflow

The Rebus Esper makes no compromises when it comes to ease of use. Preparing a run follows a simple protocol that requires less than one hour of hands-on time. Using the instrument is as easy as loading the reagents and flow cell, starting the run, and coming back at the end to collect your processed data.

Future-proofed and Flexible

With the Rebus Esper, you now have a single instrument that can run multiple optimized assays, allowing for multi-plex, multi-omic, multi-scale spatial analysis on all tissue types, regardless of treatment.

From discovery to validation to teasing apart the finest details of your hypothesis, the Rebus Esper will be able to accommodate the right assay at the right time for your research, while always delivering exceptional resolution, scale and speed.


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