SANTA CLARA, Calif. & SAN DIEGO–(BUSINESS WIRE)–Rebus Biosystems Inc, (“Rebus Bio”, “Rebus”), an Illumina Ventures-backed life science technology company creating revolutionary tools to advance spatial omics research, announced today it is partnering with Rosalind, Inc. to co-develop new spatial omics software. The technology will democratize data from single cell spatial analyses from the Rebus Esper™ […]
The throughput of the Rebus Esper has allowed us to explore brain development in a way we never could have before. Getting high sensitivity data from hundreds of thousands of cells in a single experiment enables us to tease apart details of gene regulation that will lead to a better understanding of human brain development.
SANTA CLARA, CA – March 17, 2022 – Rebus Biosystems Inc, (“Rebus Bio”, “Rebus”), an Illumina Ventures-backed life science technology company creating revolutionary tools to advance spatial omics research, announced today that Arnold Kriegstein, M.D., PhD. and Kun Zhang, PhD., have been appointed to the Company’s Scientific Advisory Board (SAB). Both Drs. Kriegstein and Zhang […]
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular […]
Rebus Bio Continues Expansion of Industry-leading Spatial Omics Platform with Breakthrough High-Plex Technology
SANTA CLARA, CA and STOCKHOLM – Dec. 8, 2021 – Rebus Biosystems Inc, (“Rebus Bio”, “Rebus”), an Illumina Ventures-backed life science technology company creating revolutionary tools to advance spatial omics research, today announced that it has acquired the IP and related assay assets of EEL Transcriptomics AB, a privately-held company focused on high-plex spatial transcriptomics with single-cell resolution. Terms […]
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Mapping the Elusive: Analysis Of Cellular Expression Using the Esper as a Method for Detailed Tissue Mapping and Structural Patterns Recognition
Brett Cook, PhD, Senior Product Manager at Rebus provides an overview of the Esper system. Marcos Otero-Garcia, PhD, Senior Scientist at Rebus, compares mouse disease models of neurodegeneration with the Esper. (11:52) Simone Codeluppi, PhD, Principal Scientist of Bioinformatics, discusses spatial organization of cell types in the mouse cortex revealed by multiplexed single-molecule fluorescent in […]
SANTA CLARA, CA – Nov. 02, 2021 – Rebus Biosystems Inc, (“Rebus Bio”, “Rebus”), an Illumina Ventures-backed life science technology company creating revolutionary tools to advance spatial omics research, today announced that Drs. Arul Chinnaiyan, MD, PhD and Sten Linnarsson, PhD, have been appointed to the Company’s Scientific Advisory Board (SAB). The two globally recognized scientific advisers bring a […]
San Francisco – Sept. 20, 2021 – Illumina Ventures, an independently-managed, healthcare-focused venture firm, announced today the closing of its second investment fund with total commitments of $325 million, bringing its total capital under management to $560 million. The latest fund is anchored by Illumina, Inc. (Nasdaq: ILMN), with the majority of the total committed capital […]
The human brain is subdivided into distinct anatomical structures, including the neocortex, which in turn encompasses dozens of distinct specialized cortical areas. Early morphogenetic gradients are known to establish early brain regions and cortical areas, but how early patterns result in finer and more discrete spatial differences remains poorly understood. Here we use single-cell RNA […]
Dr. Marcos Otero-Garcia, Sr. Scientist.
Dr. Simone Codeluppi, Principle Scientist.
Dr. Brett Cook, Sr. Product Manager.
SANTA CLARA, CA – Rebus Biosystems Inc, (“Rebus Bio”, “Rebus”), an Illumina Ventures-backed life science technology company creating revolutionary tools to advance spatial omics research, today announced Danilo Tait as the newest member of its leadership team. Tait, who holds a PhD in molecular biology from the Max-Planck Institute for Molecular Genetics and an MBA from SMC University in […]
Quantification of gene expression changes in mouse disease models using a high-throughput spatial omics platform
Batch effects due to technical variability are a major problem in single cell transcriptomics. Spatial methods are no exception – their low throughput requires high numbers of technical replicates, reducing the statistical power needed to quantify differential gene expression across experimental conditions. To overcome this problem, we took advantage of the large imaging area of […]
SANTA CLARA, CA – Rebus Biosystems, Inc., (“Rebus Bio”), an Illumina Ventures-backed life science technology company creating revolutionary tools to advance spatial omics research, today announced Tarif Awad, a highly experienced technical and commercial leader within the world of life sciences, has joined Rebus Bio as VP Scientific Affairs. “Rebus Biosystems has combined powerful Synthetic Aperture Optics microscopy with automated […]
We demonstrate the ability of the Rebus Esper platform combined with the Esper High Fidelity assay to identify all major cell types of the mouse brain and faithfully reconstruct the known tissue architecture using spatial data from only 17 cell type-specific genes and 7 reference genes.
The Rebus Esper is an integrated, automated spatial omics platform that delivers quantitative single-molecule, single-cell data with subcellular resolution.
The Esper High Fidelity assay, based on gold-standard smFISH, enables multiplex analysis of gene expression with no compromise in sensitivity or specificity.
The Rebus Esper is an integrated, automated platform that brings together advancements in imaging, fluidics, chemistry and bioinformatics to deliver spatial omics data without compromise.
The Rebus Esper makes no compromises when it comes to ease of use. Preparing a run follows a simple protocol that requires less than one hour of hands-on time. Using the instrument is as easy as loading the reagents and flow cell, starting the run, and coming back at the end to collect your processed […]
Aparna Bhaduri, PhD, Assistant Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA talks about her neuroscience research, including a deep dive into the use of Rebus Esper-enabled spatial omics data to understand the diversity of cell types across regions of the developing human cortex.
The Rebus Esper enables analysis of cells in their native tissue contexts at high throughput and provides rapid analysis of biological molecules directly in and across large tissue sections with pristine subcellular detail. Rebus Biosystems Director of Marketing Erin Davis explains more in this installment of the Spatial Omics webinar series.